Wayne Rooney is expected to return to Old Trafford for the first time since his dramatic contract wrangle last month.
Manager Sir Alex Ferguson's camp has been swept by a virus in the interim. Anderson is still struggling to overcome the bug.
Ryan Giggs is in line to take part after a hamstring strain. Brazilian right-back Rafael Da Silva is yet to fully shake off s dead leg, but Paul Scholes is back from suspension.
Owen Hargreaves is still several weeks away after he pulled up with a hamstring injury against Wolverhampton Wanderers. Michael Owen is sidelined with the same injury.