Chelsea face Premier League rivals Manchester United while Tottenham will take on Real Madrid in the Champions League quarter-finals.
Premier League champions Chelsea were drawn with Sir Alex Ferguson's Red Devils in a rematch of their 2008 European final.
League leaders United, who beat the Blues on penalties in Moscow three years ago, will enjoy home advantage in the second leg.
Tottenham were handed a glamorous but daunting clash against Real Madrid. However, they will take on the Spanish giants at White Hart Lane in the second match.
Favourites Barcelona, who conquered Arsenal in the last round, were handed one of the two supposedly easier draws and will take on Ukrainians Shakhtar Donetsk while defending champions Inter Milan will face German side Schalke 04.